Two-stage Nanoparticle Smart Bomb Targets Lung, Breast Cancer Cells
Wednesday, March 30, 2016
An international team made up of U.S. and Chinese scientists has developed a two-stage nanoparticle delivery system that has successfully targeted drug-resistant lung and breast cancer in mice.
Nanoparticle delivery systems have been tested in a variety of ways in recent years, but this new study took a two-prong approach which begins by encapsulating the chemotherapy cisplatin inside relatively large particles 100 nanometers wide to gain entry to tumors through leaky blood vessels. Once inside the tumors' acidic microenvironment, the bigger nanoparticles explode into tiny packages of cisplatin which are then activated by a second chemical process, damaging DNA and killing cancer cells. The work was published in theProceedings of the National Academy of Sciences.