New Generation of Drugs Targets Hard-to-Treat Cancers
Sunday, March 27, 2016
Source: Specialty Pharmacy Times
Recent research has provided steps towards a new generation of oncology drugs that could improve treatment for patients with therapy-resistant cancers, according to a study conducted by the University of Kent in Germany.
The biggest cause of cancer therapies failing is drug resistance. Although there have been improvements in cancer treatments, patients who develop metastatic cancer have a 5-year survival rate below 20%.
A key resistance mechanism in cancer cells is the activity of ATP-binding cassette (ABC) transporters, which are drug pumps that behave like mechanisms in order to remove anti-cancer drugs from cancer cells.