BMS, Bavarian Nordic Kick Off Combo Trial Testing Prostvac/Yervoy in Prostate Cancer

Wednesday, October 12, 2016

Source: FiercePharma

Bristol-Myers Squibb and Bavarian Nordic are getting underway with their $1 billion Prostvac clinical partnership, kicking off a Phase II trial testing Yervoy and Prostvac in early prostate cancer.

It’s the first trial in a collaboration potentially worth up to $975 million pairing BMS immunotherapies with BN’s Prostvac. The companies will test a combo of Prostvac and Yervoy in 75 patients, divided into three groups.

Patients in each group will receive either Prostvac, Yervoy or the combo, testing primarily for CD3+ T cell immune responses. For secondary milestones, investigators will measure immunologic infiltration, circulating effector T cells and regulatory T cells.

After some large-scale cancer vaccine flops in 2014 damaged the industry’s prospects, biopharma companies started exploring combination approaches that pair vaccines with checkpoint inhibitors. Since then, pharma players such as BMS, Johnson & Johnson and AstraZeneca have inked sizable collaborations with cancer vaccine biotechs to test those combos.

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